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21 Bile acids induce proliferation in hepatic stellate cells through the EGF receptor: Role of intracellular signaling pathways

✍ Scribed by F. Ridolfi; G. Svegliati-Baroni; M.H. Schoemaker; S. Saccomanno; M. Homan; P.L.M. Jansen; H. Moshage; A. Benedetti


Book ID
119631703
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
155 KB
Volume
35
Category
Article
ISSN
1590-8658

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Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t