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Bile Acid Mimetic-Activated TGR5 Receptor in Metabolic-Related Liver Disorder: The Good and the Bad

✍ Scribed by Raoul Poupon

Book ID
119761384
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
157 KB
Volume
138
Category
Article
ISSN
0016-5085

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The G-Protein-coupled bile acid receptor
The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-ΞΊB) in mice
✍ Yan-Dong Wang; Wei-Dong Chen; Donna Yu; Barry M. Forman; Wendong Huang πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 934 KB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk