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The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders

โœ Scribed by Stepanov, Vanesa; Stankov, Karmen; Mikov, Momir


Book ID
120518218
Publisher
Informa plc
Year
2013
Tongue
English
Weight
313 KB
Volume
33
Category
Article
ISSN
1079-9893

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Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo