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Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration

✍ Scribed by Verena Keitel,Maria Reich,Annika Sommerfeld…

Book ID
126380994
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
116 KB
Volume
19
Category
Article
ISSN
2047-783X

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The G-Protein-coupled bile acid receptor
The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
✍ Yan-Dong Wang; Wei-Dong Chen; Donna Yu; Barry M. Forman; Wendong Huang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 934 KB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk