Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes

✍ Scribed by Günther Loidl; Michael Groll; Hans-Jürgen Musiol; Lars Ditzel; Robert Huber; Luis Moroder

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 1012 KB
• Volume: 6
• Category: Article
• ISSN: 1074-5521
• DOI: 10.1016/s1074-5521(99)80036-2

✦ Synopsis

Background:

The 20s proteasome is a multicatalytic protease complex that exhibits trypsin-like, chymotrypsin-like and post-glutamyl-peptide hydrolytic activities associated with the active sites of the p2, p5 and /31 subunits,