✦ LIBER ✦

Bifunctional chiral synthons via biochemical methods. VIII. Optically-active 3-aroylthio-2-methylpropionic acids.

✍ Scribed by Qu-Ming Gu; D.R Reddy; C.J Sih

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 210 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85169-2

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Bifunctional chiral synthons via biochem

Bifunctional chiral synthons via biochemical methods. : VII. Optically-active 2.2′-dihydroxy-1,1′-binaphthyl.

✍ Shih-Hsiung Wu; Li-Qing Zhang; Ching-Shih Chen; Gary Girdaukas; C.J. Sih 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 199 KB

Bifunctional chiral synthons via microbi

Bifunctional chiral synthons via microbiological methods. 2. optically-active α-hydroxy aldehydes.

✍ Yoshihisa Takaishi; Yuh-Lin Yang; Dennis DiTullio; Charles J. Sih 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 204 KB

A versatile chemical-microbiological approach has been developed for the preparation of chiral a-hydroxy aldehydes via stereoselective reduction of the corresponding a-keto thioacetals or via optical resolution of the racemic a-acetoxy esters. As part of our continued interest in the preparation of

Bifunctional chiral synthons via biochem

Bifunctional chiral synthons via biochemical methods. 5. Preparation of (S)-ethyl hydrogen-3-hydroxyglutarate, key intermediate to (R)-4-amino-3-hydroxybutyric acid and L-carnitine.

✍ Aravamudan S. Gopalan; Charles J. Sih 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 201 KB

## Microbial enantioselective hydrolysis of diethyl-3-hydroxyglutarate afforded (S)-ethyl hydrogen-3_hydroxyglutarate, which was transformed into (R)-4-amino-3-hydroxybutyric acid and L-carnitine, via a Curtius and Hunsdiecker rearrangement, respectively.