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Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity

✍ Scribed by Legoix, Patricia; Bluteau, Olivier; Bayer, Jan; Perret, Christine; Balabaud, Charles; Belghiti, Jacques; Franco, Dominique; Thomas, Gilles; Laurent-Puig, Pierre; Zucman-Rossi, Jessica


Book ID
110062217
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
99 KB
Volume
18
Category
Article
ISSN
0950-9232

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Wnt/beta-catenin signaling plays an important role in liver development and regeneration. Its aberrant activation, however, is observed in a subset of primary hepatocellular cancers (HCCs). In the current study, we compare and contrast the tumor characteristics of HCC in the presence or absence of m