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Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

✍ Scribed by Yong-Kang Zhang; Jacob J. Plattner; Yvonne R. Freund; Eric E. Easom; Yasheen Zhou; Long Ye; Huchen Zhou; David Waterson; Francisco-Javier Gamo; Laura M. Sanz; Min Ge; Zhiya Li; Lingchao Li; Hailong Wang; Han Cui


Book ID
113496533
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
848 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract 5‐Fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole (AN2690) is a new antifungal agent for the potential treatment of onychomycosis. During the preclinical development phase, it was necessary to synthesize the radioisotope [3‐^14^C]‐5‐fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole and the