✦ LIBER ✦

An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

✍ Scribed by Yong-Kang Zhang; Jacob J. Plattner; Eric E. Easom; David Waterson; Min Ge; Zhiya Li; Lingchao Li; Yong Jian

Book ID: 118501509
Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 313 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.05.088

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Benzoxaborole antimalarial agents. Part

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

✍ Yong-Kang Zhang; Jacob J. Plattner; Yvonne R. Freund; Eric E. Easom; Yasheen Zho 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 848 KB

ChemInform Abstract: Benzoxaborole Antim

ChemInform Abstract: Benzoxaborole Antimalarial Agents. Part 2. Discovery of Fluoro-Substituted 7-(2-Carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

✍ Yong-Kang Zhang; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 25 KB

Benzoxaborole antimalarial agents. Part

Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

✍ Yong-Kang Zhang; Jacob J. Plattner; Eric E. Easom; Liang Liu; Daniel M. Retz; Mi 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 French ⚖ 283 KB

Synthesis of isotopically labelled [3-14

Synthesis of isotopically labelled [3-14C]- and [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis

✍ Stephen J. Baker; Yong-Kang Zhang; Tsutomu Akama; Conrad Wheeler; Jacob J. Platt 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 113 KB

## Abstract 5‐Fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole (AN2690) is a new antifungal agent for the potential treatment of onychomycosis. During the preclinical development phase, it was necessary to synthesize the radioisotope [3‐^14^C]‐5‐fluoro‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole and the

Discovery of a New Boron-Containing Anti

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

✍ Baker, Stephen J.; Zhang, Yong-Kang; Akama, Tsutomu; Lau, Agnes; Zhou, Huchen; H 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 66 KB

An efficient synthesis of a class of nov

An efficient synthesis of a class of novel N-Alkyl-N-aryl-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinecarbothioamides

✍ Glen W. Spears; Kiyoshi Tsuji; Takashi Tojo; Hiroaki Nishimura; Takashi Ogino 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 68 KB

## Abstract The novel title compounds have been prepared in high yield by an optimized amide coupling followed by a Dieckmann cyclization. Additionally, this new route is amenable to preparative scale synthesis.