๐”– Bobbio Scriptorium
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Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

โœ Scribed by Andrzej W. Lipkowski; Aleksandra Misicka; Frank Porreca; Peg Davis; Hank I. Yamamura; Dagmar Stropova; Victor J. Hruby

Book ID
104628408
Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
334 KB
Volume
2
Category
Article
ISSN
1573-3149

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โœฆ Synopsis

The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr ~ and Phe 4 in opioid peptides are similar for interactions with both 5 and ~c receptor types.

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