✦ LIBER ✦
Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers
✍ Scribed by James A Patch; Annelise E Barron
- Book ID
- 104414725
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 85 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1367-5931
No coin nor oath required. For personal study only.
✦ Synopsis
Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.