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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

✍ Scribed by Cherney, Robert J.; Mo, Ruowei; Meyer, Dayton T.; Pechulis, Anthony D.; Guaciaro, Michael A.; Lo, Yvonne C.; Yang, Gengjie; Miller, Persymphonie B.; Scherle, Peggy A.; Zhao, Qihong; Cvijic, Mary Ellen; Barrish, Joel C.; Decicco, Carl P.; Carter, Percy H.


Book ID
122378186
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
595 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract The 1‐cyclohexyl substituted 3‐aminopyrrolidine derivatives having a morpholine or thiomorpholine at the C‐4 position of the cyclohexyl group (II) are found to be good CCR2 antagonists.