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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

โœ Scribed by Cherney, Robert J.; Mo, Ruowei; Meyer, Dayton T.; Nelson, David J.; Lo, Yvonne C.; Yang, Gengjie; Scherle, Peggy A.; Mandlekar, Sandhya; Wasserman, Zelda R.; Jezak, Heather; Solomon, Kimberly A.; Tebben, Andrew J.; Carter, Percy H.; Decicco, Carl P.


Book ID
126812620
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
110 KB
Volume
51
Category
Article
ISSN
0022-2623

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Synthesis and Pharmacological Profile of New 1,3-Disubstituted Cyclohexanes as Leukotriene B4 Receptor Antagonists. -Novel non-aromatic members of stable leukotriene B4 antagonists such as (VIII) and (IX) are described, in which the conjugated double bond of the natural eicosanoid (X) is replaced b