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Benzimidazol-Derivate und verwandte Heterocyclen VI. Synthese von Phenyl-[1-aminoalkyl-benzimidazolyl-(2)]-essigsäure-estern und -amiden

✍ Scribed by A. Hunger; J. Kebrle; A. Rossi; K. Hoffmann


Publisher
John Wiley and Sons
Year
1960
Tongue
German
Weight
457 KB
Volume
43
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The synthesis of a series of phenyl‐[1‐aminoalkyl‐benzimidazolyl‐(2)]‐acetic esters and amides is described. Some of the derivatives prepared show pronounced analgesic activity.


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Benzimidazol-Derivate und verwandte Hete
✍ A. Hunger; J. Kebrle; A. Rossi; K. Hoffmann 📂 Article 📅 1960 🏛 John Wiley and Sons 🌐 German ⚖ 899 KB

## Abstract The synthesis of a series of 1‐aminoalkyl‐2‐benzyl‐nitro‐benzimidazoles is described. Many of the 5‐nitro‐benzimidazoles prepared show strong analgesic activity. 1‐(β‐Diethylamino‐ethyl)‐2‐(p‐ethoxy‐benzyl)‐5‐nitro‐benzimidazole (XXXVIII) is 1000 times as potent as morphine and therefor