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Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen

✍ Scribed by A. Hunger; J. Kebrle; A. Rossi; K. Hoffmann

Publisher: John Wiley and Sons
Year: 1960
Tongue: German
Weight: 899 KB
Volume: 43
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19600430412

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✦ Synopsis

Abstract

The synthesis of a series of 1‐aminoalkyl‐2‐benzyl‐nitro‐benzimidazoles is described. Many of the 5‐nitro‐benzimidazoles prepared show strong analgesic activity. 1‐(β‐Diethylamino‐ethyl)‐2‐(p‐ethoxy‐benzyl)‐5‐nitro‐benzimidazole (XXXVIII) is 1000 times as potent as morphine and therefore the most active analgesic known until now.

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