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Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR)

✍ Scribed by Suzanne Pieper; Dorothée Out; Marian J. Bakermans-Kranenburg; Marinus H. van IJzendoorn

Publisher
Springer
Year
2011
Tongue
English
Weight
102 KB
Volume
24
Category
Article
ISSN
0894-9867

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✦ Synopsis

Abstract

We evaluated the role of the serotonin transporter gene promoter polymorphism (5‐HTTLPR) in the etiology of dissociation. Adult twin pairs (N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5‐HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5‐HTTLPR reported more dissociative symptoms compared to participants with the other genotypes (p = .02), and they showed more pathological dissociative symptoms than the other participants (p = .04) when they reported more depressive symptoms and when they had experienced trauma.

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