Becker muscular dystrophy: Clinical, biochemical, and molecular genetic correlations
โ Scribed by Serenella Servidai; Giuliana Galluzzi; Enrico Bertini; Giovanni Manfredi; Enzo Ricci; Aldo Broccolini; Massimiliano Mirabella; Antonella Spinazzola; Alice M. Donati; Pietro Tonall
- Book ID
- 119173426
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 127 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-8994
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๐ SIMILAR VOLUMES
Recent advances in molecular genetics have led to the isolation of the gene defective in patients with Duchenne and Becker's muscular dystrophy and the characterization of its protein product, dystrophin. In this communication, the developments culminating in the identification of the Duchenne muscu
A total of 56 Duchenne muscular dystrophy (DMD) patients and 11 Becker muscular dystrophy (BMD) patients was analyzed by extended "multiplex" amplification of the DMD/BMD gene; deletions were found in 60% of these patients. The data obtained were used to test the frameshift hypothesis and to compare