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Molecular biology of duchenne and Becker's muscular dystrophy: Clinical applications

โœ Scribed by David H. Gutmann; Kenneth H. Fischbeck

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
646 KB
Volume
26
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

Recent advances in molecular genetics have led to the isolation of the gene defective in patients with Duchenne and Becker's muscular dystrophy and the characterization of its protein product, dystrophin. In this communication, the developments culminating in the identification of the Duchenne muscular dystrophy locus are reviewed. The practical applications of this research and pitfalls that limit prenatal diagnosis and carrier detection are discussed.

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We think that the article by contains inaccurate and misleading information. The first important criticism is the title, which implies that longitudinal data on the clinical course of the disease are to be presented. This can only be measured by observation over a period of time, and no such data w