Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast cancer
β Scribed by Shinichi Tsutsui; Kazuhiro Yasuda; Kosuke Suzuki; Hideya Takeuchi; Takashi Nishizaki; Hidefumi Higashi; Shoichi Era
- Book ID
- 115010828
- Publisher
- BioMed Central
- Year
- 2006
- Tongue
- English
- Weight
- 442 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1471-2407
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Recent studies have shown bcl-2 to be regulated by p53. Other studies have suggested an inverse relationship between p53 and bcl-2 protein expression in breast and colonic cancers and in a variety of subtypes of non-Hodgkin's lymphoma. This study investigates the relationship between bcl-2 and p53 p
## Abstract Strong expression of human epidermal growth factor receptor 2 (HERβ2)/neu in breast cancer has been associated with poor prognosis. Reduced expression of p27^Kip1^, a cyclinβdependent kinase inhibitor, correlates with poor clinical outcome in breast cancer. In this study, we provide a c