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bcl-2 expression in the spectrum of preinvasive breast lesions

✍ Scribed by Kalliopi P. Siziopikou; John E. Prioleau; Jay R. Harris; Stuart J. Schnitt

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
800 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

The bcI-2 gene encodes for a protein that blocks apoptosis. Although the Ocl-2 protein has been identified in some invasive breast cancers, its expression in preinvasive breast lesions has not been well characterized.

METHODS.

We studied bcl-2 expression using immunohistochemistry in cases of normal breast tissue (n = lo), ductal hyperplasia ( t i = 181, atypical ductal hyperplasia (ADH) (n = lo), atypical lobular hyperplasia/lobular carcinoma in situ (lobular neoplasia, LN) (n = lo), and ductal carcinoma in situ (DCIS) (n = 42). We also related bcl-2 expression to p53 expression in these lesions because the p53 gene is altered in many invasive breast cancers and is also involved in the regulation of apoptosis.

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The expression of the pro-apoptotic proteins (Bax, Bak) and anti-apoptotic proteins (Bcl-2, Bcl-X, Mcl-1) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas. The results were correlated with tumour grade, expression of oestrogen receptor (ER) and p53 protein, and the apopto