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Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

✍ Scribed by Jacobson, Michael D.; Burne, Julia F.; King, Michael P.; Miyashrta, Toshiyuki; Reed, John C.; Raff, Martin C.

Book ID
109783068
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
666 KB
Volume
361
Category
Article
ISSN
0028-0836

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Lonidamine (LND), a selective inhibitor of the energy metabolism of tumor cells, induces apoptosis, independently of the p53 gene, in the adriamycin(ADR)-resistant MCF7 breast-cancer cell line (MCF7 ADR). On the contrary, LND fails to activate the apoptotic program in the parental MCF7-sensitive cel