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Bayesian guidelines for phase II clinical trial design and analysis

✍ Scribed by Peter F. Thall; Richard Simon


Book ID
113297513
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
63 KB
Volume
13
Category
Article
ISSN
0197-2456

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Many popular sequential phase II clinical trial designs optimize some criterion subject to constraints on the error probabilities at null and alternative values of the response rate. Such designs may forfeit optimality if one fails to conduct analyses strictly according to plan. Moreover, a decision