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A Bayesian approach to the design of phase II clinical trials

✍ Scribed by Richard J. Sylvester


Book ID
113297310
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
82 KB
Volume
12
Category
Article
ISSN
0197-2456

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Many popular sequential phase II clinical trial designs optimize some criterion subject to constraints on the error probabilities at null and alternative values of the response rate. Such designs may forfeit optimality if one fails to conduct analyses strictly according to plan. Moreover, a decision