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Basic hydrolysis of glyceryl nitrate esters. I. 1-glyceryl and 2-glyceryl nitrate esters

✍ Scribed by C. Capellos; W. J. Fisco; C. Ribaudo; V. D. Hogan; J. Campisi; F. X. Murphy; T. C. Castorina; D. H. Rosenblatt

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
670 KB
Volume
14
Category
Article
ISSN
0538-8066

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✦ Synopsis

Abstract

Kinetics of the basic hydrolysis of 1‐glyceryl mononitrate (1‐MNG) and 2‐glyceryl mononitrate (2‐MNG) were investigated in CO~2~‐free aqueous calcium hydroxide solutions. The hydrolysis reactions were carried out in a temperature‐controlled reactor vessel with provision for continuous N~2~ sparging of the reaction mixture. Both glyceryl nitrate esters hydrolyzed via second‐order reaction at 25°C. 2‐MNG in calcium hydroxide solution isomerized to 1‐MNG, which subsequently hydrolyzed to form NO. In strongly basic aqueous solutions of NaOH (30%), 2‐MNG is converted to glycidol and NO.

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