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Phosphono-platelet activating factor I. synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency

✍ Scribed by Michael C. Moschidis; Constantinos A. Demopoulos; Lena G. Kritikou

Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
278 KB
Volume
33
Category
Article
ISSN
0009-3084

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✦ Synopsis

The total synthesis of 1-O-alkyl-2-acetyl-3-glyceryl-(2-trimethyl ammoniummethyl)phosphonate, the phosphono analogue of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcho~ne, is described. The phosphonolipid shows much lower activity than the phospholipid stimulating serotonin release from rabbit platelets.

πŸ“œ SIMILAR VOLUMES

Phosphono-platelet activating factor. II
Phosphono-platelet activating factor. II. Synthesis of 2-acetamido-2-deoxy-1-O-octadecylglycerol-3-(2-trimethylammoniumethyl) and (2-aminoethyl)phosphonates
✍ Michael C. Moschidis; Constantin A. Demopoulos πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 English βš– 306 KB

The chemical synthesis of the amide analogs of 1-O-alkyl-2-O-acet yl-glyceryl-3-O-phosphoryl cholinc as its phosphono analog (phosphono-AGEPC)and 1-O-alkyl-2-O-acetyl-glyceryl-3-Ophosphoryl ethanolamine as its phosphono analog (phosphono-AGEPE) is reported. The intermediate acetamides for the subse