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Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

✍ Scribed by Brian Plosky; Leona Samson; Bevin P Engelward; Barry Gold; Brenda Schlaen; Themistocles Millas; Michael Magnotti; Jonathan Schor; David A Scicchitano

Book ID: 117798854
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 244 KB
Volume: 1
Category: Article
ISSN: 1568-7864
DOI: 10.1016/s1568-7864(02)00075-7

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## Abstract Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by which mammalian cells repair alkylation damage to DNA and involves the processing of relati