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BAK1 gene variation and abdominal aortic aneurysms—results may have been prematurely overrated

✍ Scribed by Sébastien Küry; Fabrice Airaud; Philippe Piloquet; Stéphane Bézieau

Book ID
102259648
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
237 KB
Volume
31
Category
Article
ISSN
1059-7794

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We thank Ku ¨ry et al. [2010] for their letter. They raise a number of issues with regard to our initial article that reported on variations in BAK1 gene (MIM] 600516) sequence expressed in the abdominal aorta (AA) tissue when compared with leukocyte genomic DNA sequence . In a subsequent letter , w

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✍ Bruce Gottlieb; Lorraine E. Chalifour; Benjamin Mitmaker; Nathan Sheiner; Daniel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB

We sought to examine the role of genetics in the multifactorial disease, abdominal aortic aneurysm (AAA), by studying sequence variation in the BAK1 gene (BAK1) that codes for an apoptotic-promoting protein, as chronic apoptosis activation has been linked to AAA development and progression. BAK1 abd