A response to: BAK1 gene variation and abdominal aortic aneurysms—results may have been prematurely overrated. Questions of sequence fidelity, intraorganismal genetic heterogeneity, the nature of pseudogenes, and RNA editing
✍ Scribed by Bruce Gottlieb; Lorraine E. Chalifour; Morris Schweitzer
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 97 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1059-7794
No coin nor oath required. For personal study only.
✦ Synopsis
We thank Ku ¨ry et al. [2010] for their letter. They raise a number of issues with regard to our initial article that reported on variations in BAK1 gene (MIM] 600516) sequence expressed in the abdominal aorta (AA) tissue when compared with leukocyte genomic DNA sequence . In a subsequent letter , we noted that when we compared the genomic BAK1 sequence in matching blood and tissue samples, the blood and tissue BAK1 genomic sequences were identical to the reference BAK1 genomic sequence, which primarily suggested that an unusual form of RNA editing could possible be involved.
Ku ¨ry et al. [2010] have raised three issues with regard to possible explanations for our results.
a This sequence has the same citation as the reference sequence NC_000020.10