Bactericidal activities of radical species generated by catalytic reaction of iron(III) octacarboxyphthalocyanine

✍ Scribed by Takashi Ichinohe; Makoto Miyajima; Yasuhisa Noguchi; Masahiko Ito; Mutsumi Kimura; Toshiki Koyama; Kenji Hanabusa; Akira Hachimori; Hirofusa Shirai

• Book ID: 101289099
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 87 KB
• Volume: 02
• Category: Article
• ISSN: 1088-4246
• DOI: 10.1002/(sici)1099-1409(199803/04)2:2<101::aid-jpp54>3.0.co;2-7

✦ Synopsis

Strong bactericidal activities against various bacteria were observed in the reaction system of iron(III) octacarboxyphthalocyanine ( Fe ^III^ - oapc ) and tert-butyl hydroperoxide (tert-BuOOH). The kinetics of the decomposition of tert-BuOOH catalysed by Fe ^III^ -oapc were studied in buffered solutions between pH 5 to 12 using gas chromatography analysis. The rate of catalytic decomposition of tert-BuOOH followed second-order kinetics in tert-BuOOH concentrations. The second-order rate constant (k~2~) had a maximum value at pH 11. Oxygen evolution was observed at high tert-BuOOH concentration, while oxygen consumption was observed at low tert-BuOOH concentration. The former indicates plural radical chain reactions of the tert-butoxyl radical and the latter suggests decomposition of the tert-butoxyl radical to acetone and methyl radical. By the electron spin resonance spin trapping method using 5,5-dimethyl-1-pyrroline-N-oxide and α-phenyl-N-tert-butylnitrone it was found that the radical species generated in the reaction system is tert-butoxyl radical, which plays crucial roles in bactericidal activities.