Reaction of 5,6,7,8-Tetrahydropterin with Iron(III) Acetylacetonate. Detection of Radical Cations by Electrospray Ionization Mass Spectrometry

✍ Scribed by Andrea Schäfer; Manfred Hesse; Max Viscontini; Henning Paul; Berthold Fischer

• Book ID: 102859873
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: German
• Weight: 670 KB
• Volume: 78
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19950780710

✦ Synopsis

Abstract

The experimental conditions developed for the detection of rather stable radical cations in solution by electrospray‐ionization mass spectrometry (ESI‐MS) of a Fe^II^ complex of 2‐amino‐5,6,7,8‐tetrahydro‐5‐methylpteridin‐4 (3__H__)‐one (1c) are used to observe the formation of the more unstable radical cations formed from 2‐amino‐5,6,7,8‐tetrahydropteridin‐4(3__H__)‐one (1a) and tris(pentane‐2,4‐dionato)iron(III) ([Fe^III^(acac)~3~]; 4) and to monitor their oxidation to the corresponding p‐quinonoid dihydropterin complexes. These results contribute to the understanding of the important role played by 6β‐5,6,7,8‐tetrahydro‐L‐biopterin (1b; a homologue of 1a) together with iron as constituent of some cofactors. The complexes obtained from 1a and iron may be considered, e.g. as a model of the cofactor of the phenylalanine hydroxylase. Moreover, we describe an improved synthesis of 1c.