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Baclofen costs justified in severe spasticity


Book ID
120871577
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
1999
Weight
210 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize