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Intrathecal baclofen in severe spasticity

✍ Scribed by Delhaas, E.M.; Spit, J.M.; Kums, J.J.M.

Book ID
122873780
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
127 KB
Volume
92
Category
Article
ISSN
0303-8467

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πŸ“œ SIMILAR VOLUMES

CSF Baclofen levels after intrathecal ad
CSF Baclofen levels after intrathecal administration in severe spasticity
✍ B. Sallerin-Caute; Y. Lazorthes; B. Monsarrat; J. Cros; R. Bastide πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 283 KB

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize