CSF Baclofen levels after intrathecal administration in severe spasticity

✍ Scribed by B. Sallerin-Caute; Y. Lazorthes; B. Monsarrat; J. Cros; R. Bastide

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 283 KB
• Volume: 40
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00265844

✦ Synopsis

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).