## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5β² part of __NU
Backtracking to birth of the NUP98-HOXD13 gene fusion in an infant acute myeloid leukemia
β Scribed by Emerenciano, M; Meyer, C; Macedo-Silva, M L; de Meis, E; Dobbin, J A; Marschalek, R; Pombo-de-Oliveira, M S
- Book ID
- 109887475
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 210 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0887-6924
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## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1
The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part