## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor
B7-DC-silenced dendritic cells induce stronger anti-HBV immunity in transgenic mice
✍ Scribed by Yan Fan; Wen-Zheng Jiang; Jie-Jun Wen; Wen-Li Hao; Jia-Ni Du; Xia Liu; Min Qian
- Publisher
- Springer Vienna
- Year
- 2009
- Tongue
- English
- Weight
- 290 KB
- Volume
- 154
- Category
- Article
- ISSN
- 1432-8798
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The present study demonstrates that the transfection of B7-I or its variant MB7-2 genes into MHC class I+ tumor cells (B 16-BL6 or K I 735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the
## Abstract To study the gene expression profiles in dendritic cells (DCs) from a hepatitis B surface antigen (HBsAg) positive host, transcriptional analysis of bone marrow ‐derived DCs from a lineage of HBsAg transgenic mice (#59) was compared to DCs from normal mice. Among the immune‐related gene