B-RAF mutations in tumors from melanoma-breast cancer families

✍ Scribed by Andreas Gast; Asta Försti; Magnus Söderberg; Kari Hemminki; Rajiv Kumar

• Book ID: 102268973
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 52 KB
• Volume: 113
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20560

✦ Synopsis

Dear Sir,

As one of the first results from the Swedish Family-Cancer Database, we described in 1997 a strong familial clustering of breast cancers and melanomas at the population level. 1 In a follow-up study, more such families were identified and the high risks were confirmed. 2 For example, in offspring of mothers with breast cancer, the familial standardized incidence ratio (SIR) for melanoma was 5.70 (CI ϭ 2.59 -10.04) when the father had melanoma, compared to an SIR of 1.14 (CI ϭ 1.02-1.27) when the father had no cancer. The offspring risk for breast cancer in such families was 4.74 (CI ϭ 2.67-7.44