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Breast-cancer risk in BRCA-mutation-negative women from BRCA-mutation-positive families

✍ Scribed by Hormuzd A Katki; Mitchell H Gail; Mark H Greene


Book ID
117784528
Publisher
The Lancet
Year
2007
Tongue
English
Weight
42 KB
Volume
8
Category
Article
ISSN
1470-2045

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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie