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B cell repertoire and ageing

โœ Scribed by Deborah K Dunn-Walters; Alexander A Ademokun


Book ID
108099672
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
383 KB
Volume
22
Category
Article
ISSN
0952-7915

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he enormous diversity of immunoglobulin (Ig) specificities is the product of combinatorial joining of a relatively limited number of germline genes, and the subsequent somatic hypermutation of the rearranged genes. The resulting diversity comes at a price. First, self-reactive antibodies are generat