Apoptosis fashions T and B cell repertoire
β Scribed by Laszlo Fesus
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 423 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0165-2478
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Self-renewal is generally thought to play a major role in the maintenance of the T-cell repertoire. Here we develop a set of mathematical models for T-cell activation by peptides on antigen presenting cells (APCs). We show that competition between \(T\) cells is inherent to the processes involved in
he enormous diversity of immunoglobulin (Ig) specificities is the product of combinatorial joining of a relatively limited number of germline genes, and the subsequent somatic hypermutation of the rearranged genes. The resulting diversity comes at a price. First, self-reactive antibodies are generat