B-CELL DEVELOPMENT: Plasma-cell differentiation requires Blimp1
โ Scribed by Honey, Karen
- Book ID
- 109953974
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 75 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri1274
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The initial phases of B cell development depend on interactions between the cell surface molecules and secreted products of stromal cells with their receptor-ligand partners on lymphoid progenitors. Recent research in this area has greatly advanced our understanding of B cell development and differe
B lymphocyte-induced maturation protein-1 (Blimp-1) can drive plasmacytic differentiation in cultured cell models. To determine the role of Blimp-1 in B cell development in vivo, we have generated transgenic mice expressing an interfering truncated form of Blimp-1 (TBlimp) under the control of an im