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✦   LIBER   ✦

An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells

✍ Scribed by Cristina Angelin-Duclos; Kristen Johnson; Jerry Liao; Kuo-I Lin; Kathryn Calame

Book ID
101382023
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
377 KB
Volume
32
Category
Article
ISSN
0014-2980

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✦ Synopsis

B lymphocyte-induced maturation protein-1 (Blimp-1) can drive plasmacytic differentiation in cultured cell models. To determine the role of Blimp-1 in B cell development in vivo, we have generated transgenic mice expressing an interfering truncated form of Blimp-1 (TBlimp) under the control of an immunoglobulin heavy chain promoter and intronic (E) enhancer. TBlimp-transgenic mice have elevated serum IgM and a prolonged IgM response. This effect is due to an increased number of short-lived, IgM-secreting plasma cells resulting from increased proliferation and prolonged survival. In addition, TBlimp-transgenic mice have a developmental defect in the generation of mature B cells in the spleen. These results show that in vivo Blimp-1 plays a fundamental role in the control of the life span and exit from the cell cycle of IgM secreting plasma cells.

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✍ David Tarlinton; Irmgard Förster; Klaus Rajewsky 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 1010 KB

Mott cells are a variant form of plasma cell in which the immunoglobulin (Ig), rather than being secreted, accumulates in rough endoplasmic reticulum-derived vesicles called Russell bodies. We have examined the molecular cause of this defect and the in vivo origin of IgM Mott cells. Our examination