B cell development and differentiation

✍ Scribed by Peter D Burrows; Max D Cooper

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 549 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80142-2

✦ Synopsis

The initial phases of B cell development depend on interactions between the cell surface molecules and secreted products of stromal cells with their receptor-ligand partners on lymphoid progenitors. Recent research in this area has greatly advanced our understanding of B cell development and differentiation. Antigen receptors on pre-B and B cells play key roles in the progression of this differentiation process, as revealed by targeted and inherited gene mutations that disrupt B cell development and by the transgenic repair of these mutations in mice.