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B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit mice

✍ Scribed by Karen Lipovsky; Lori A Bennett; Jichun Chen


Book ID
113615657
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
339 KB
Volume
31
Category
Article
ISSN
0301-472X

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## Abstract The cytokine IL‐7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL‐7 receptor α‐deficient mice. We demonstrate that the IL‐7 receptor becomes progressively more important with age.