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Hyperresponsive B Cells in CD22-Deficient Mice

✍ Scribed by O'Keefe, T. L.; Williams, G. T.; Davies, S. L.; Neuberger, M. S.

Book ID: 121156958
Publisher: American Association for the Advancement of Science
Year: 1996
Tongue: English
Weight: 818 KB
Volume: 274
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.274.5288.798

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## Abstract CD22‐deficient mice are characterized by B cell hyperactivity and autoimmunity. We have constructed knock‐in CD22^–/–^ mice, expressing an anti‐DNA heavy (H) chain (D42), alone or combined with Vκ1‐Jκ1 or Vκ8‐Jκ5 light (L) chains. The Ig‐targeted mice produced a lupus‐like serology that