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Azathioprine metabolite levels tailored to achieve clinical responsiveness in Crohn's disease

✍ Scribed by Cuffari, Carmen; Hunt, Sharon; Mann, Jandeep; Bayless, Theodore

Book ID: 123515404
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 173 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(00)85285-3

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## Background: To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD). ## Methods: A cohort of 327 unrelated Spanish patients with CD recruited from