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MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease

✍ Scribed by Juan L. Mendoza; Elena Urcelay; Raquel Lana; M. Carmen Martín; Natalia López; Luis G. Guijarro; Julio A Mayol; Carlos Taxonera; Emilio G. de la Concha; Amado S. Peña; Manuel Díaz-Rubio

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
91 KB
Volume
13
Category
Article
ISSN
1078-0998

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✦ Synopsis

Background:

To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).

Methods:

A cohort of 327 unrelated Spanish patients with CD recruited from a single center was studied. All patients were rigorously followed up for at least 2 years (mean time, 11.5 years). A case-control analysis of MDR1 G2677T/A and C3435T SNPs and 2 loci haplotypes in 112 steroid-dependent CD patients treated with azathioprine was performed. Patients were classified on the basis of response to azathioprine.

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