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Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis

✍ Scribed by Yanfang Li; Wei Hu; De-Yu Shen; John J. Kavanagh; Siqing Fu

Book ID: 113433974
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 569 KB
Volume: 200
Category: Article
ISSN: 1097-6868
DOI: 10.1016/j.ajog.2008.08.030

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## Abstract Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur __via__ epigenetic mechanisms. Down‐regulation of expression of argininosuccinate synthetase (ASS1), the rate‐limiting enzyme in the biosynthesis of arginine, has been associated with the develop