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Improvement of sensitivity to platinum compound with siRNA knockdown of upregulated genes in platinum complex-resistant ovarian cancer cells in vitro

✍ Scribed by Hironobu Yanagie; Tomoyuki Hisa; Aya Ogata; Ayaka Miyazaki; Yasumasa Nonaka; Teturo Nishihira; Isao Osada; Takayuki Sairennji; Hirotaka Sugiyama; Yoshitaka Furuya; Yosinori Kidani; Shinichi Takamoto; Hiroyuki Takahashi; Masazumi Eriguchi


Book ID
116313986
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
406 KB
Volume
63
Category
Article
ISSN
0753-3322

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## Abstract Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur __via__ epigenetic mechanisms. Down‐regulation of expression of argininosuccinate synthetase (ASS1), the rate‐limiting enzyme in the biosynthesis of arginine, has been associated with the develop