## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c
โฆ LIBER โฆ
Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer
โ Scribed by Siqing Fu; Wei Hu; Revathy Iyer; John J. Kavanagh; Robert L. Coleman; Charles F. Levenback; Anil K. Sood; Judith K. Wolf; David M. Gershenson; Maurie Markman; Bryan T. Hennessy; Razelle Kurzrock; Robert C. Bast Jr
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 298 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
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## Background and Objectives: We assessed the role of salvage chemotherapy with topotecan and cisplatin in patients with platinum-and paclitaxel-resistant advanced and recurrent ovarian or primary peritoneal cancer, based on the reported in vivo and in vitro synergism between these two drugs. Meth