Role of salvage chemotherapy with topotecan and cisplatin in patients with paclitaxel- and platinum-resistant recurrent ovarian or primary peritoneal cancer: A phase II pilot study
✍ Scribed by Ghamande, Sharad A.; Piver, M. Steven
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 56 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background and Objectives:
We assessed the role of salvage chemotherapy with topotecan and cisplatin in patients with platinum-and paclitaxel-resistant advanced and recurrent ovarian or primary peritoneal cancer, based on the reported in vivo and in vitro synergism between these two drugs. Methods: Twenty patients were entered in this phase II trial from November 1997 to November 1998. They received cisplatin at 50 mg/m 2 on day 1 with topotecan at 0.6 mg/m 2 from day 1 to 5 every 28 days. In 70% of patients (14/20), this combination represented at least a third line of therapy.
Results: A clinical response rate of 13.3% (two partial responses) was obtained in the 15 patients with evaluable disease. Sixty percent of patients (9/15) had stable disease and 26.7% (4/15) had progression. The median progression-free interval and survival were 4 months and 7 months, respectively. The 20 patients evaluable for toxicity received a mean of four chemotherapy cycles. Dose reductions were required in 45% of patients despite the administration of growth factors. The major dose-limiting toxicity was a 50% occurrence (10/20) of grade 4 thrombocytopenia and 30% (6/20) grade 4 neutropenia. There was one septic death. Conclusions: These data suggest that combination therapy with topotecan and cisplatin has minimal activity in platinum-and paclitaxel-resistant advanced and recurrent ovarian or primary peritoneal cancer at the doses utilized in this trial.